Chronic use of tramadol after acute pain episode: Cohort study. Clinical interpretation of urine drug tests: What clinicians need to know about urine drug screens. First report on the pharmacokinetics of tramadol and O-desmethyltramadol in exhaled breath compared to plasma and oral fluid after a single oral dose. Oral fluid drug testing in pain management practice: Factors to consider before choosing the alternative biological matrix. Hair drug testing results and self-reported drug use among primary care patients with moderate-risk illicit drug use. Tramadol, pharmacology, side effects, and serotonin syndrome: A review. Cognitive impairment and tramadol dependence. Tramadol pill alone may cause serotonin syndrome. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. If you’re taking tramadol, it’s important to take the time to read the warnings on the label, and to talk to your doctor or pharmacist if you have any concerns or questions. Avoid driving or operating machinery while taking tramadol. It can also affect the way you process visual and spatial details. Avoid breastfeeding while taking tramadol. Tramadol can also reach your baby through your breastmilk. Let your doctor know immediately if you are or think you might be pregnant. ![]() If you’re pregnant, taking tramadol can harm your baby. Life-threatening effects for developing fetuses. ![]() If tramadol is ingested by a child or pet, it can cause serious side effects, including death. If you’re taking tramadol, keep it in a safe and secure place. Tramadol is processed differently by children, dogs, and cats. Life-threatening effects for children and pets. Make sure your doctor knows what you’re taking. You shouldn’t drink alcohol or use certain drugs while taking tramadol. This can reduce tramadol’s effectiveness and in some cases, cause serious side effects. Tramadol may interact with other medications you’re taking. If you’re worried about tramadol dependence, talk to your doctor.ĭrug interactions. You can avoid this by gradually reducing your dose. If this happens and you stop taking it, you might experience withdrawal symptoms. Tramadol is habit-forming, which means that you can become dependent on it. Tramadol use comes with additional risks. Other side effects are less common, but may be serious. More common side effects of tramadol include: If you take more than prescribed, you’re also increasing your risk of side effects. In general, the risk of side effects increases according to how much you take. Tramadol comes with a risk of mild to severe side effects. If you’re over 75, it may take your body longer to get rid of tramadol. Reduced kidney or liver function can increase the amount of time it takes for your body to get rid of tramadol. ![]() Having a slow metabolism may increase the amount of time it takes to break down tramadol. Your metabolic rate can be affected by many things, including your activity level, age, diet, body composition, and genetics. Metabolism refers to the chemical process of breaking down substances that you ingest, such as food or medication. In general, tramadol drops or injections are absorbed and excreted faster than pill forms of the medication.
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